Research in the MezeyLab is supported by Cornell University and Weill Cornell Medicine, the National Institutes of Health (NIH), the National Science Foundation (NSF), and Private Foundations. Listed below are NIH grants that have been supporting MezeyLab research within the last three years. For information on additional / previous NIH, NSF, and Foundation grant support, please see Dr. Mezey's CV or please contact us at
NIH/NBIB - R01 EB027918
Rapid Noninvasive Whole-body Imaging of AAV Gene Transfer Vectors
PIs Ballon and Crystal
The focus of this project is to develop a noninvasive method to assess the biodistribution of AAV gene transfer using radiolabeling technology to study viral vector biodistribution of AAV administered intravenously or intracisternally to nonhuman primates.
07/01/19-03/31/22 / Reporter
NIH/NIA - U01 DA048524
Clinical Assessment of Anti-cocaine Vaccine dAdGNE in Cocaine Addicts
The hypothesis of this project is linking a cocaine analog to Ad capsid proteins would elicit high-affinity, high-titer antibodies against cocaine, sufficient to sequester systemically administered drug from access to the brain, with consequent reduction in cocaine-induced behavior.
02/01/19 – 01/31/22 / Reporter
NIH/NHLBI - R01 HL118541
Integrative-omics Network Model of the Disordered COPD Small Airway Epithelium
PIs Crystal and Mezey
The purpose of this grant is to analyze the influence of genetic, epigenetic and miRNA expression variability on key transcriptome modules, hubs and connectivities that define how small airway epithelium biology becomes disordered with the development of COPD.
08/15/14-06/30/21 / Reporter
NIH/NHLBI - R41 HL145871
Gene Therapy to Protect the Lung from Oxidant Stress
The goal of this project is the development of a gene therapy to protect the lung with an extracellular anti-oxidant defense to treat chronic obstructive pulmonary disease (COPD).
09/23/19 – 08/31/20 / Reporter
NIH/NIDCR - R01 HL134163
In Vivo Biomarker that Identifies Waterpipe Smoking-Related Lung Health
The focus of this study is to assess airway and nasal epithelial transcriptome and measures of lung health to determine if the nasal epithelial transcriptome can be used as a biomarker of lung toxicity resulting from waterpipe smoking.
09/01/16-08/31/20 / Reporter
NIH/NIDA - U01 HL121828
HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium
PI Crystal and Gross
The hypothesis of this study is that HIV infection of alveolar macrophages results in a chronic, exaggerated oxidant stress in the lower respiratory tract that mediates programmed cell death of the pulmonary capillary endothelium, contributing to the development of emphysema.
09/26/13-07/31/19 / Reporter
NIH/NIDCR - R56 DE026027
Biology of the Oral Epithelium of E-Cigarette Smokers
PIs Crystal and Mezey
The hypothesis underlying this proposal is that chronic e-cigarette smoking disorders the biology of the oral epithelium, the first cell population exposed to inhaled e-cigarette vapors.
03/03/16-02/28/19 / Reporter
NIH/NHLBI - R01 HL118857
HIV-related Accelerated Aging of the Airway Epithelium
These studies will help unravel the pathogenesis of the HIV-associated development of COPD, help identify new targets for pharmacologic intervention and add to the evidence that tight control of HIV infection may be useful in reducing the incidence of HIV-associated COPD.
05/22/13-02/28/19 / Reporter