Funding

 

Research in the MezeyLab is supported by Cornell University and Weill Cornell Medicine, the National Institutes of Health (NIH), the National Science Foundation (NSF), and Private Foundations. Listed below are NIH grants that have been supporting MezeyLab research within the last three years.  For information on additional / previous NIH, NSF, and Foundation grant support, please see Dr. Mezey's CV or please contact us at MezeyLab

 


NIH/NBIB - R01 EB027918

Rapid Noninvasive Whole-body Imaging of AAV Gene Transfer Vectors

PIs Ballon and Crystal

The focus of this project is to develop a noninvasive method to assess the biodistribution of AAV gene transfer using radiolabeling technology to study viral vector biodistribution of AAV administered intravenously or intracisternally to nonhuman primates.

07/01/19-03/31/22 / Reporter

 


NIH/NIA - U01 DA048524

Clinical Assessment of Anti-cocaine Vaccine dAdGNE in Cocaine Addicts

PI Crystal

The hypothesis of this project is linking a cocaine analog to Ad capsid proteins would elicit high-affinity, high-titer antibodies against cocaine, sufficient to sequester systemically administered drug from access to the brain, with consequent reduction in cocaine-induced behavior.

02/01/19 – 01/31/22 / Reporter

 


NIH/NHLBI - R01 HL118541

Integrative-omics Network Model of the Disordered COPD Small Airway Epithelium

PIs Crystal and Mezey

The purpose of this grant is to analyze the influence of genetic, epigenetic and miRNA expression variability on key transcriptome modules, hubs and connectivities that define how small airway epithelium biology becomes disordered with the development of COPD.

08/15/14-06/30/21 / Reporter

 


NIH/NHLBI - R41 HL145871

Gene Therapy to Protect the Lung from Oxidant Stress

PI Crystal

The goal of this project is the development of a gene therapy to protect the lung with an extracellular anti-oxidant defense to treat chronic obstructive pulmonary disease (COPD).

09/23/19 – 08/31/20 / Reporter

 


NIH/NIDCR - R01 HL134163

In Vivo Biomarker that Identifies Waterpipe Smoking-Related Lung Health

PI Crystal

The focus of this study is to assess airway and nasal epithelial transcriptome and measures of lung health to determine if the nasal epithelial transcriptome can be used as a biomarker of lung toxicity resulting from waterpipe smoking.

09/01/16-08/31/20 / Reporter

 


NIH/NIDA - U01 HL121828

HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium

PI Crystal and Gross

The hypothesis of this study is that HIV infection of alveolar macrophages results in a chronic, exaggerated oxidant stress in the lower respiratory tract that mediates programmed cell death of the pulmonary capillary endothelium, contributing to the development of emphysema.

09/26/13-07/31/19 / Reporter

 


NIH/NIDCR - R56 DE026027

Biology of the Oral Epithelium of E-Cigarette Smokers

PIs Crystal and Mezey

The hypothesis underlying this proposal is that chronic e-cigarette smoking disorders the biology of the oral epithelium, the first cell population exposed to inhaled e-cigarette vapors.

03/03/16-02/28/19 / Reporter

 


NIH/NHLBI - R01 HL118857

HIV-related Accelerated Aging of the Airway Epithelium

PI Crystal

These studies will help unravel the pathogenesis of the HIV-associated development of COPD, help identify new targets for pharmacologic intervention and add to the evidence that tight control of HIV infection may be useful in reducing the incidence of HIV-associated COPD.

05/22/13-02/28/19 / Reporter