Mezey Group

All publications listed are in review or published in peer reviewed academic journals where the work described was performed by the MezeyLab member listed as first, co-first, or senior (corresponding) author during their tenure in the MezeyLab.

In Review

A Systematic Framework for Assessing the Clinical Impact of Polygenic Risk Scores

Scott Kulm, Andrew Marderstein, Jason Mezey and Olivier Elemento

Synopsis@KulmScott

April 2021 pdf / MedRxiv

 


In Review

Simple Linear Cancer Risk Prediction Models with Novel Features Outperform Complex Approaches

Scott Kulm, Lior Kofman, Jason Mezey and Olivier Elemento

Synopsis@KulmScott

January 2021 pdf / MedRxiv

 


Mobile DNA

The Derepression of Transposable Elements in Lung Cell is Associated with the Inflammatory Response and Gene Activation in Idiopathic Pulmonary Fibrosis

Mahboubeh Rostami and Martina Bradic

June 2021 pdf / Google Scholar / Pubmed

 


BMC BIOINFORMATICS

Identifying Novel Associations in GWAS by Hierarchical Bayesian Latent Variable Detection of Differentially Misclassified Phenotypes

Afrah Shafquat, Ronald G. Crystal and Jason G. Mezey

May 2020 pdf / Google Scholar / Pubmed

 


AMERICAN JOURNAL OF HUMAN GENETICS

Inferring Identical-by-Descent Sharing of Sample Ancestors Promotes High-Resolution Relative Detection

Monica D. Ramstetter, Sushila A. Shenoy, Thomas D. Dyer, Donna M. Lehman, Joanne E. Curran, Ravindranath Duggirala, John Blangero, Jason G. Mezey and Amy L. Williams

July 2018 pdf / Google Scholar / Pubmed

 


GENETICS

Benchmarking Relatedness Inference Methods with Genome-Wide Data from Thousands of Relatives

Monica D. Ramstetter, Thomas D. Dyer, Donna M. Lehman, Joanne E. Curran, Ravindranath Duggirala, John Blangero, Jason G. Mezey and Amy L. Williams 

September 2017 pdf / Google Scholar / Pubmed

 


PLOS COMPUTATIONAL BIOLOGY

An Independent Component Analysis Confounding Factor Correction Framework for Identifying Broad Impact expression Quantitative Trait Loci

Jin Hyun Ju, Sushila A. Shenoy, Ronald G. Crystal and Jason G. Mezey

May 2017 pdf / Google Scholar / Pubmed

 


NATURE COMMUNICATIONS

Open access resources for genome-wide association mapping in rice

Susan R. McCouch, Mark H. Wright, Chih-Wei Tung, Lyza G. Maron, Kenneth L. McNally, Melissa Fitzgerald, Namrata Singh, Genevieve DeClerck, Francisco Agosto-Perez, Pavel Korniliev, Anthony J. Greenberg, Ma Elizabeth B. Naredo, Sheila Mae Q. Mercado, Sandra E. Harrington, Yuxin Shi, Darcy A. Branchini, Paula R. Kuser-Falcão, Hei Leung, Kowaru Ebana, Masahiro Yano, Georgia Eizenga, Anna McClung and Jason Mezey 

February 2016 pdf / Google Scholar / Pubmed / Corrigendum

 


GENOME RESEARCH

Indigenous Arabs are Descendants of the Earliest Split From Ancient Eurasian Populations

Juan L. Rodriguez-Flores, Khalid Fakhro, Francisco Agosto-Perez, Monica D. Ramstetter, Leonardo Arbiza, Thomas L. Vincent, Amal Robay, Joel A. Malek, Karsten Suhre, Lotfi Chouchane, Ramin Badii, Ajayeb Al-Nabet Al-Marri, Charbel Abi Khalil, Mahmoud Zirie, Amin Jayyousi, Jacqueline Salit, Alon Keinan, Andrew G. Clark, Ronald G. Crystal and Jason G. Mezey

Synopsis@juansearch / Genome Research Cover

February 2016 pdf / Google Scholar / Pubmed

 


BIOINFORMATICS

lrgpr: Interactive Linear Mixed Model Analysis of Genome-Wide Association Studies with Composite Hypothesis Testing and Regression Diagnostics in R

Gabriel E. Hoffman, Jason G. Mezey and Eric E. Schadt

July 2014 pdfGoogle Scholar / Pubmed

 


BIOINFORMATICS

HEFT: eQTL Analysis of Many Thousands of Expressed Genes While Simultaneously Controlling for Hidden Factors

Chuan Gao, Nicole L. Tignor, Jacqueline Salit, Yael Strulovici-Barel, Neil R. Hackett, Ronald G. Crystal and Jason G. Mezey

February 2014 pdfGoogle Scholar / Pubmed 

 


HUMAN MUTATION

Exome Sequencing Identifies Potential Risk Variants for Mendelian Disorders at High Prevalence in Qatar

Juan L Rodriguez-Flores, Khalid Fakhro, Neil R. Hackett, Jacqueline Salit, Jennifer Fuller, Francisco Agosto-Perez, Maey Gharbiah, Joel A. Malek, Mahmoud Zirie, Amin Jayyousi, Ramin Badii, Ajayeb Al-Nabet Al-Marri, Lotfi Chouchane, Dora J. Stadler, Jason G. Mezey and Ronald G. Crystal

January 2014 pdfGoogle Scholar / Pubmed

 


PLOS ONE

Correcting for Population Structure and Kinship Using the Linear Mixed Model: Theory and Extensions

Gabriel E. Hoffman

October 2013 pdfGoogle Scholar / Pubmed / Correction

 


JOURNAL OF MACHINE LEARNING RESEARCH

Sub-Local Constraint-Based Learning of Bayesian Networks Using a Joint Dependency Criterion

Rami Mahdi and Jason Mezey

June 2013 pdfGoogle Scholar

 


PLOS COMPUTATIONAL BIOLOGY

PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data

Gabriel E. Hoffman, Benjamin A. Logsdon and Jason G. Mezey

June 2013 pdf / Google Scholar / Pubmed

 


PLOS ONE

Exome Sequencing of Only Seven Qataris Identifies Potentially Deleterious Variants in the Qatari Population

Juan L. Rodriguez-Flores, Jennifer Fuller, Neil R. Hackett, Jacqueline Salit, Joel A. Malek, Eman Al-Dous, Lotfi Chouchane, Mahmoud Zirie, Amin Jayoussi, Mai A. Mahmoud, Ronald G. Crystal and Jason G. Mezey

November 2012 pdf / Google Scholar / Pubmed

 


BMC GENETICS

Inferring Genome-Wide Patterns of Admixture in Qataris Using Fifty-Five Ancestral Populations

Larsson Omberg, Jacqueline Salit, Neil Hackett, Jennifer Fuller, Rebecca Matthew, Lotfi Chouchane, Juan L. Rodriguez-Flores, Carlos Bustamante, Ronald G. Crystal and Jason G. Mezey

June 2012 pdf / Google Scholar / Pubmed

 


BIOINFORMATICS

Empirical Bayes Conditional Independence Graphs for Regulatory Network Recovery

Rami Mahdi, Abishek S. Madduri, Guoqing Wang, Yael Strulovici-Barel, Jacqueline Salit, Neil R. Hackett, Ronald G. Crystal and Jason G. Mezey

June 2012 pdf / Google Scholar / Pubmed

 


BMC BIOINFORMATICS

Mouse Obesity Network Reconstruction with a Variational Bayes Algorithm to Employ Aggressive False Positive Control

Benjamin A. Logsdon, Gabriel E. Hoffman and Jason G. Mezey

April 2012 pdf / Google Scholar / Pubmed

 


GENETIC EPIDEMIOLOGY

Fast, Exact Linkage Analysis for Categorical Traits on Arbitrary Pedigree Designs

Abra Brisbin, Jenifer Cruickshank, N. Sydney Moïse, Teresa Gunn, Carlos D. Bustamante and Jason G. Mezey

July 2011 pdf / Google Scholar / Pubmed

 


PLOS ONE

Bayesian Linkage Analysis of Categorical Traits for Arbitrary Pedigree Designs

Abra Brisbin, Myrna M. Weissman, Abby J. Fyer, Steven P. Hamilton, James A. Knowles, Carlos D. Bustamante and Jason G. Mezey

August 2010 pdf / Google Scholar / Pubmed

 


PLOS COMPUTATIONAL BIOLOGY

Gene Expression Network Reconstruction by Convex Feature Selection When Incorporating Genetic Perturbations

Benjamin A. Logsdon and Jason G. Mezey

December 2010 pdf / Google Scholar / Pubmed

 


BMC BIOINFORMATICS

A Variational Bayes Algorithm for Fast and Accurate Multiple Locus Genome-Wide Association Analysis

Benjamin A. Logsdon, Gabriel E. Hoffman and Jason G. Mezey

January 2010 pdf / Google Scholar / Pubmed